Virology Journal
Volume 3
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 Short reportGenomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swineStanley I Martin  , Robert Wilkinson and Jay A Fishman  Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114, USA  author email corresponding author email
Virology Journal 2006,
3:91doi:10.1186/1743-422X-3-91
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| Published: |
2 November 2006 |
Abstract
The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo. | 
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