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Compounds that reduce rotavirus infectivity without cytotoxicity |
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| Manufacturer's ID Number |
Chemical Name |
FW |
Chemical Family |
Known Functions (Select references) |
|
|
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| Group A |
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| TNP00130 |
18-β-Glycyrrhetinic Acid |
470.68 |
Triterpene |
-Antiviral activity against a number of DNA and RNA viruses [25] -Inhibits gap junction communication |
| TNP00088 |
Abietic Acid |
302.45 |
Diterpene |
-Inhibits acute inflammation after topical or oral administration [26] -Reduces neutrophil infiltration [26] -Reduces COX-2 and TNF-α expression [16] -Activates PPAR-γ in macrophages [16] |
| TNP00194 |
All-trans-Retinoic Acid |
300.44 |
Retinoid |
-Increases expression of type I interferon receptors [27] |
| TNP00140 |
α-Mangostin |
410.46 |
Xanthone |
-Used in treatment of skin infections, wounds and diarrhea in Southeast Asia [15] -γ-Mangostin inhibits NF-κB activation and COX-2 expression [15] -α-Mangostin preferentially inhibits growth of HL60 cells [28] -Induces caspase-9 and -3 activation in HL60 cells [28] |
| Group B |
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| TNP00307 |
Kinetin-9-Riboside |
347.33 |
Phytohormone |
-Cytokinin -Antiviral activity against Tobacco Mosaic Virus [29] -Causes a decrease in (poly rI) (poly rC) stimulated interferon response in VSV challenged mice [30] -Reverses the effect of endotoxin-enhanced host resistance [31] |
| TNP00064 |
7,3'-Dihydroxyflavone |
254.24 |
Flavone |
|
| TNP00050 |
6,7-Dimethoxyflavone |
282.29 |
Flavone |
|
| TNP00044 |
8-Hydroxy-7-Methoxyflavone |
268.27 |
Flavone |
|
| TNP00151 |
Genistein |
270.24 |
Isoflavone |
-Tyrosine kinase inhibitor [32] -Down-regulates iNOS [33] -Inhibits NF-κB activation [33] -Inhibits COX-2 induction [33] -Inhibits LPS induced IL-1β, IL-6, and TNF-α production in monocytes |
| TNP00227 |
Capsaicin |
305.42 |
Phenylalkyl-Amine Alkaloid |
-Inhibits NF-κB activation [34] -Activates transient receptor potential vanilloid-1 (TRPV-1) [35] |
| TNP00256 |
Securinine |
217.26 |
Pseudoalkaloid |
-GABA receptor antagonist -Antibacterial activity against E. coli, Staph. aureus and Myc. smegmatis [36] -Antimalarial activity [37] |
| TNP00231 |
Isopimaric Acid |
302.46 |
Diterpene |
-Inhibitory activity against multidrug-resistant strains of Staphylococcus aureus [38] -activates large-conductance Ca2+-activated K+ channel α-subunit [39] |
| TNP00292 |
Parthenolide |
248.32 |
Sesquiterpene Lactone |
-inhibits NFκB activation by preventing induction of IκB kinase [40] |
| TNP00006 |
Unknown |
358.48 |
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| TNP00014 |
Unknown |
388.50 |
||
Shaneyfelt et al. Virology Journal 2006 3:68 doi:10.1186/1743-422X-3-68 |
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