Sequence alignment of Family B DNA polymerases from the Archaea, Bacteria and Eukarya domains. The Mimivirus PolB sequence was used without its intein sequence. Only the region of the alignment around Mimivirus intein insertion site ("YGD|TDS") is shown. The insertion site precisely coincides with the most conserved positions in the sequences, as indicated by bold letters. This is the sole region in the entire sequence exhibiting 6 consecutive identical residues among PolB of the Archaea, Bacteria and Eukarya domains. SWISS-PROT/TrEMBL IDs are DPOL_ARCFU (Archaeoglobus fulgidus), Q8TWJ5 (Methanopyrus kandleri), DPO2_ECOLI (Escherichia coli), Q87NC2 (Vibrio parahaemolyticus), Q8SQP5 (Encephalitozoon cuniculi), and DPOD_HUMAN (Human).
Ogata et al. Virology Journal 2005 2:8 doi:10.1186/1743-422X-2-8