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Open Access Highly Accessed Review

Human herpesvirus 8 – A novel human pathogen

Daniel C Edelman

Author Affiliations

University of Maryland Baltimore, School of Medicine, Department of Pathology, 725 West Lombard Street, Rm. S407, Baltimore, Maryland 21201, USA

Virology Journal 2005, 2:78  doi:10.1186/1743-422X-2-78

Published: 2 September 2005

Abstract

In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8) [1]. This novel herpesvirus has and continues to present challenges to define its scope of involvement in human disease. In this review, aspects of HHV-8 infection are discussed, such as, the human immune response, viral pathogenesis and transmission, viral disease entities, and the virus's epidemiology with an emphasis on HHV-8 diagnostics.