Genetic lesions within the 3a gene of SARS-CoV

doi:10.1186/1743-422X-2-51

Virology Journal

Volume 2

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Tan TH
Barkham T
Fielding BC
Chou CF
Shen S
Lim SG
Hong W
Tan YJ

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Barkham T
Fielding BC
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Shen S
Lim SG
Hong W
Tan YJ
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Short report

Genetic lesions within the 3a gene of SARS-CoV

Timothy HP Tan¹ , Timothy Barkham² , Burtram C Fielding¹ , Chih-Fong Chou¹ , Shuo Shen¹ , Seng Gee Lim¹ , Wanjin Hong¹ and Yee-Joo Tan¹

¹Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673 Singapore

²Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433 Singapore

author email corresponding author email

Virology Journal 2005, 2:51doi:10.1186/1743-422X-2-51


Published:	20 June 2005

Abstract

A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.