Log on / register
BioMed Central home | Journals A-Z | Feedback | Support | My details
Open AccessMethodology

Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses

Catherine H Schein1,3 email, Bin Zhou1 email and Werner Braun1,2 email

Sealy Center for Structural Biology, Department of Human Biology, Chemistry and Genetics, University of Texas Medical Branch at Galveston, TX, USA

Sealy Center for Vaccine Development, Department of Human Biology, Chemistry and Genetics, University of Texas Medical Branch at Galveston, TX, USA

Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, TX, USA

author email corresponding author email

Virology Journal 2005, 2:40doi:10.1186/1743-422X-2-40

Published: 21 April 2005

Additional files

Additional File 1:

Multiple sequence alignment (CLUSTAL W (1.82)) of 14 flavirus envelope sequences. Escape mutant positions are bold, the conserved residues in domains I (Y59, C60, C121) and III (F306, Y326) that are near escape mutants common to several flaviviruses are in red. Corresponding residues that are variant in the yellow fever 17D strain are in bold and underlined.

Format: DOC Size: 41KB Download file

This file can be viewed with: Microsoft Word Viewer


© 1999-2010 BioMed Central Ltd unless otherwise stated. Part of Springer Science+Business Media.