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Prospective study of Hepatitis E Virus infection among pregnant women in France

Christophe Renou1, Vincent Gobert2, Christophe Locher2, Abdelouahab Moumen3, Oumar Timbely3, Janine Savary4, Anne-Marie Roque-Afonso456* and Association Nationale des Hépato-Gastroentérologues des Hôpitaux Généraux (ANGH)

Author Affiliations

1 Hôpital de Jour, Centre Hospitalier d’Hyères, Hyères 83407, France

2 Maladies de l’Appareil Digestif, Centre Hospitalier de Meaux, Meaux 77104, France

3 Gynécologie-Obstétrique-Maternité, Centre Hospitalier de Meaux, Meaux 77104, France

4 AP-HP, Hôpital Paul Brousse, Virologie, Villejuif 94804, France

5 Univ Paris-Sud, UMR-S 785, Villejuif 94804, France

6 INSERM U785, Villejuif 94804, France

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Virology Journal 2014, 11:68  doi:10.1186/1743-422X-11-68

Published: 9 April 2014



Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. This prospective study was conducted to assess HEV infection in this setting.


An overall HEV prevalence of 7.74% was observed among 315 pregnant women. Seroprevalence was higher in south than in north of France (29.3% vs. 3.6%, p < 0.0001), and women with detectable IgG were older. No IgG seroconversion or IgM detection were observed during pregnancy.


Data suggest that HEV infection is a rare occurrence during pregnancy even in regions of western countries with high seroprevalence rates.

HEV; Seroprevalence; Pregnancy; France