Prospective study of Hepatitis E Virus infection among pregnant women in France
1 Hôpital de Jour, Centre Hospitalier d’Hyères, Hyères 83407, France
2 Maladies de l’Appareil Digestif, Centre Hospitalier de Meaux, Meaux 77104, France
3 Gynécologie-Obstétrique-Maternité, Centre Hospitalier de Meaux, Meaux 77104, France
4 AP-HP, Hôpital Paul Brousse, Virologie, Villejuif 94804, France
5 Univ Paris-Sud, UMR-S 785, Villejuif 94804, France
6 INSERM U785, Villejuif 94804, France
Virology Journal 2014, 11:68 doi:10.1186/1743-422X-11-68Published: 9 April 2014
Hepatitis E Virus (HEV) infection has a poor prognosis among pregnant women from high endemic countries. HEV-prevalence and incidence among pregnant women is unknown in high-income countries such as France. This prospective study was conducted to assess HEV infection in this setting.
An overall HEV prevalence of 7.74% was observed among 315 pregnant women. Seroprevalence was higher in south than in north of France (29.3% vs. 3.6%, p < 0.0001), and women with detectable IgG were older. No IgG seroconversion or IgM detection were observed during pregnancy.
Data suggest that HEV infection is a rare occurrence during pregnancy even in regions of western countries with high seroprevalence rates.