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Open Access Short report

Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population

Rajesh Panigrahi1, Avik Biswas1, Binay Krishna De2, Sekhar Chakrabarti3 and Runu Chakravarty1*

Author Affiliations

1 ICMR Virus Unit, Kolkata, ID & BG Hospital Campus, Kolkata, India

2 Department of Medicine, Calcutta Medical College, Kolkata, West Bengal, India

3 National Institute of Cholera and Enteric Diseases, Kolkata, India

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Virology Journal 2013, 10:56  doi:10.1186/1743-422X-10-56

Published: 14 February 2013

Abstract

Background

Antiviral therapy using nucleos(t)ide analogues (NAs) is an effective control measure of chronic hepatitis B virus (HBV) infection; however they need long term treatment. Presence of drug-resistance mutations may get in the way of the efficacy of antiviral therapy. Our study was aimed at defining the prevalence of HBV drug-resistance in HBVrt region in a population of 147 HBsAg positive patients.

Findings

HBV/D has shown multiple types of HBVrt mutations both among treatment naïve (65.0%, 13 of 20 HBV/D) and treated patients (56.2%, 9 of 16 HBV/D). In additional, several mutations, with a suggested role in drug resistance, were detected among the treatment naïve as well as the treated patients. The mutations reported to be involved in reduction of drug effectiveness, was common among non-responders to therapy as well as among the naïve patients. Notably, classical antiviral resistance mutations (rtL80I/V-rtI169T-rtV173L-rtL180M-rtA181T/V/S-rtT184A/S/G/C-rtA194T-rtS202C /G/I -rtM204V/I-rtN236T-rtM250V) were not detected.

Conclusion

The prevalence of putative NAr mutations among non responders to therapy suggests that they might have role in reduced efficacy of currently available antivirals and requires further investigations.

Keywords:
HBV infection; Drug resistance; Drug-naïve patients; Eastern India