Flowchart of study selection. Systematic search strategies were applied to identify all reports on patients’ kidney function during MERS-CoV infection. Data sources used were Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/ webcite) and Promed.Mail (http://www.promedmail.org webcite) by searching the term “coronavirus” with a date range from 15th September 2012 (date of the first MERS-CoV report) to 16th September 2013. All identified publications were reviewed for clinical data on kidney function (irrespective of pointing to normal or impaired function). Data on patient sex and age, country of patient origin and travel route, onset of illness, presence or absence of ARF, date of onset of ARF, day of illness on which ARF occurred, as well as clinical outcome (death or survival) were extracted. In total, 7 publications were finally included that described a total of 12 MERS-CoV patients and their kidney function during the course of disease.
Eckerle et al. Virology Journal 2013 10:359 doi:10.1186/1743-422X-10-359