Table 1

Cellular factors cleaving Tat (http://www.ncbi.nlm.nih.gov/projects/RefSeq/HIVInteractions/ webcite)
Protein name Protein Acc Ref PMID Interaction description
Calpain-1 catalytic subunit NP_005177.2 19022302 Calpain-mediated cleavage of HIV-1 Tat occurs in the C-terminus of this viral protein, between amino acids 68 and 69. The cleavage of Tat by calpain 1 increases neurotoxic effect of this viral protein
Furin preproprotein NP_002560.1 15135058 Furin cleaves HIV-1 Tat at amino acid residue 56, resulting in greatly reduced Tat transactivation activity

Bagashev and Sawaya

Bagashev and Sawaya Virology Journal 2013 10:358   doi:10.1186/1743-422X-10-358

Open Data