Table 1

Clinical description and outcome of Nipah virus challenged ferrets
Group-subject no. Clinical illnessa Viralb load Clinical and gross pathology
1-1 Fever (d5-7); Depression (d6-7); lethargy (d6-7); loss of appetite (d6-7); labored breathing (d6-7). Animal euthanized on d7. ++/6, ++/7 Thrombocytopenia (d7); Lymphopenia (d6-7); >3-fold increase in BUN (d7); rash on ventral surface of neck; lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver, edema of left kidney capsule.
1-2 Fever (d5); depression (d6-8); lethargy (d6-8) loss of appetite (d6-8); labored breathing (d6-8); dehydration (d8), ocular and nasal discharge (d7-8); Hind limb paresis (d8) Animal euthanized on d8. ++/6, ++/8 Thrombocytopenia (d8); Lymphopenia (d6,8); >3-fold increase in BUN (d8); hypoalbuminemia (d6,8); ecchymotic rash on ventral surface of neck; lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver.
1-3 Fever (d4-7); depression (d5-7); lethargy (d5-7); loss of appetite (d5-7); labored breathing (d6-7); ocular and nasal discharge (d6-7); Hind limb paresis (d7). Animal euthanized d7. ++/6, ++/7 Thrombocytopenia (d6-7); Lymphopenia (d6-7); hypoalbuminemia (d6-7); ecchymotic rash on ventral surface of neck; lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver.
1-4 Fever (d5-7); Depression (d6-8); lethargy (d7-8); loss of appetite (d6-8); labored breathing (d6-8); hind limb tremors (d8). Animal euthanized on d8. ++/6, ++/8 Thrombocytopenia (d8); Lymphopenia (d6,8); hypoalbuminemia (d8); lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver.
1-5 Fever (d5-7); Depression (d6-7); lethargy (d7); loss of appetite (d5-7); dehydration (d7); labored breathing (d6-7). Animal euthanized on d7. ++/6, ++/7 Thrombocytopenia (d7); Lymphopenia (d6-7); hypoalbuminemia (d7); lungs with severe congestion and hemorrhage of all lobes; enlarged spleen; darkened liver.
2-1 None None
2-2 None +/6 None
2-3 None None
2-4 None None
2-5 Mild fever (d7) +/6 None
3-1 None None
3-2 None None
3-3 None +/6 None
3-4 None None
3-5 None +/6 None
4-1 None None
4-2 None None
4-3 None +/6 None
4-4 None +/6 None
4-5 None None

aAnimals euthanized due to complications from NiV-induced disease.

bqRT-PCR positive blood/day p.c.: +, ≤ 5 log10 NiVM GEq/ml of blood; ++, ≥ 5 log10 NiVM GEq /ml of blood.

Mire et al.

Mire et al. Virology Journal 2013 10:353   doi:10.1186/1743-422X-10-353

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