Phylogenetic trees of 5'UTR, P1, P2 and P3 regions of EV71 and CVA16 strains with complete genome sequences. The trees were inferred from 5′UTR (A), P1 (B), P2 (C) and P3 (D) region data by ML method, with bootstrap values calculated from 1000 trees. Sequences for 751 nucleotide positions in each 5′UTR, 2586 nucleotide positions in each P1 region, 1734 nucleotide positions in each P2 region and 2259 nucleotide positions in each P3 region were included in the analysis. Black circles and squares indicate EV71 isolates of subgenotype C4 (proposed genotype D) and those of subgenotype C2 respectively from Hong Kong in the present study. CVA16 prototype strain G-10 is highlighted in grey.
Yip et al. Virology Journal 2013 10:222 doi:10.1186/1743-422X-10-222