Dermatologic presentations of atypical HFMD. Erythema was frequently observed at the base of large vesicles. These lesions were distributed on limbs, trunks or perioral areas. (Top, left) Bullae were formed on a 5 year-old boy’s sole, which caused mild pruritus and prickling sensations. (Top, right) Atypical rashes of CVA6 spread on a 4 year-old child’s forehead and temporal area of the face. The lesions did not involve the cornea or conjunctiva. (Bottom, left) Late presentation of atypical HFMD, severe desquamation was presented on bilateral palms and soles of a 12 year-old boy. Ten days earlier, he had marked blisters on his bilateral limbs and scattered vesicles on his buttock, yet without fever or other systemic symptoms. (Bottom, right) Onychomadesis occurred on the 2 weeks post CVA6 infection.
Huang et al. Virology Journal 2013 10:209 doi:10.1186/1743-422X-10-209