Table 4

Locations and details of genome nucleotide positions containing variation
Case Gene nt Dom base (freq) Alt base (freq) Total Cov Var % Log LH (AA) Log LH (AB) Log LH (BB) S or NS. Amino Acid
C PA 184 A(116) C(11) 127 9 −48 −38 −501 NS I62L
D PA 1800 T(114) C(18) 131 14 −77 −39 −524 S S600
D HA 844 A(103) G(33) 136 24 −142 −41 −478 NS I282V
D PB1 437 C(106) T(22) 126 18 −98 −38 −450 NS T146I
D PB1 796 C(103) A(20) 123 16 −86 −37 −430 NS L266I
D PB1 1791 C(96) A(35) 131 27 −149 −39 −407 NS N597K
D NA 458 G(128) A(10) 138 7 −48 −42 −552 NS S153N
D NA 823 T(134) C(4) 138 97 −624 −41 −17 NS H275Y

Footnotes: ‘nt’ refers to nucleotide position. ‘Dom’ refers to dominant nucleotide. ‘Alt’ refers to alternative nucleotide. ‘Cov’ refers to sequence coverage. ‘Freq’ refers to frequency. ‘Var’ refers to level (%) of variant. ‘Log LH’ refers to log likelihood, where AA represents no variation from the reference, BB represents 100% variation from the reference and AB represents some variation from the reference. ‘S’ and ‘NS’ indicates synonymous and non-synonymous amino acid substitutions. The bold text highlights the variation associated with the NA H275Y, oseltamivir-resistance conferring substitution.

Fordyce et al.

Fordyce et al. Virology Journal 2013 10:116   doi:10.1186/1743-422X-10-116

Open Data