Table 1

Histologic lesions of CDV-infected raccoons.

Raccoon

Sex

M/Ya

Siteb

Presentation

Encephalitisf

Pneumoniah

Other findings

EMCVk


98-2645

F

8/98

FPc

Euthanized

++; Demyelination; axonal loss; few IBg

+++; Chronic; no IB

Lymphoid depletion (LNi); IB – other sites

-

98-2646

M

8/98

ZGd

Dead

-

++; Sub-acute to chronic; no IB

IB – other sitesj

-

98-2654

M

10/98

ZG

Euthanized

Rare axonal loss

++

Ocular discharge; CDV in footpad ("Hardpad" disease); lymphoid depletion (LN and spleen)

-

98-2655

F

10/98

ZG

Dead

++; IB common

None

Lymphoid depletion (LN and spleen); IB – other sites

-

98-2666

F

12/98

ZG

Euthanized

++; Axonal loss; rare neuronal IB

++; Chronic; no IB

Lymphoid depletion (LN and spleen); IB – other sites

-

00-2601

M

1/00

ZG

Euthanized

++; Rare neuronal IB; severe axonal loss

None

IB – other sites

-

01-2641

M

5/01

OFPe

Euthanized

+; IB; syncytia in hippocampus

+++ with syncytia; IB

Lymphoid depletion (LN and spleen); IB – other sites

+ brain, LN, spleen)

01-2663

F

6/01

ZG

Euthanized

None

+++ with syncytia; IB

Lymphoid depletion (LN and spleen); IB – other sites

-

01-2676

F

7/01

ZG

Euthanized

+; Axonal loss; neuronal necrosis; IB; syncytia in hippocampus

+++; IB

Lymphoid depletion (LN); IB – other sites

-

01-2689

F

8/01

ZG

Euthanized

+; IB

++ with syncytia; IB

Lymphoid depletion (LN and spleen); IB – other sites; rhinitis; purulent conjunctivitis

-

01-2690

M

8/01

ZG

Euthanized

Rare neuronal necrosis; IB

None

Lymphoid depletion (LN); IB – other sites

+ (spleen)


aM/Y; Month and year animal examined by necropsy and specimens frozen.

bSite; Location where animal was trapped or found dead.

cFP; Forest preserve at border of zoo.

dZG; Zoo grounds.

eOFP; Off-site forest preserve

fEncephalitis: -, none; +, mild; ++, moderate.

gIB; Characteristic intracytoplasmic or intranuclear inclusion bodies formed by Canine distemper virus.

hPneumonia: +, mild; ++, moderate; +++, severe.

iLN; Lymph node.

JIB – other sites: Inclusion bodies in other epithelial sites.

kEMCV, Encephalomyocarditis virus.

Lednicky et al. Virology Journal 2004 1:2   doi:10.1186/1743-422X-1-2

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