Table 1

Histologic lesions of CDV-infected raccoons.

Raccoon
Sex
M/Ya
Siteb
Presentation
Encephalitisf
Pneumoniah
Other findings
EMCVk

98-2645
F
8/98
FPc
Euthanized
++; Demyelination; axonal loss; few IBg
+++; Chronic; no IB
Lymphoid depletion (LNi); IB – other sites
-
98-2646
M
8/98
ZGd
Dead
-
++; Sub-acute to chronic; no IB
IB – other sitesj
-
98-2654
M
10/98
ZG
Euthanized
Rare axonal loss
++
Ocular discharge; CDV in footpad ("Hardpad" disease); lymphoid depletion (LN and spleen)
-
98-2655
F
10/98
ZG
Dead
++; IB common
None
Lymphoid depletion (LN and spleen); IB – other sites
-
98-2666
F
12/98
ZG
Euthanized
++; Axonal loss; rare neuronal IB
++; Chronic; no IB
Lymphoid depletion (LN and spleen); IB – other sites
-
00-2601
M
1/00
ZG
Euthanized
++; Rare neuronal IB; severe axonal loss
None
IB – other sites
-
01-2641
M
5/01
OFPe
Euthanized
+; IB; syncytia in hippocampus
+++ with syncytia; IB
Lymphoid depletion (LN and spleen); IB – other sites
+ brain, LN, spleen)
01-2663
F
6/01
ZG
Euthanized
None
+++ with syncytia; IB
Lymphoid depletion (LN and spleen); IB – other sites
-
01-2676
F
7/01
ZG
Euthanized
+; Axonal loss; neuronal necrosis; IB; syncytia in hippocampus
+++; IB
Lymphoid depletion (LN); IB – other sites
-
01-2689
F
8/01
ZG
Euthanized
+; IB
++ with syncytia; IB
Lymphoid depletion (LN and spleen); IB – other sites; rhinitis; purulent conjunctivitis
-
01-2690
M
8/01
ZG
Euthanized
Rare neuronal necrosis; IB
None
Lymphoid depletion (LN); IB – other sites
+ (spleen)

aM/Y; Month and year animal examined by necropsy and specimens frozen.

bSite; Location where animal was trapped or found dead.

cFP; Forest preserve at border of zoo.

dZG; Zoo grounds.

eOFP; Off-site forest preserve

fEncephalitis: -, none; +, mild; ++, moderate.

gIB; Characteristic intracytoplasmic or intranuclear inclusion bodies formed by Canine distemper virus.

hPneumonia: +, mild; ++, moderate; +++, severe.

iLN; Lymph node.

JIB – other sites: Inclusion bodies in other epithelial sites.

kEMCV, Encephalomyocarditis virus.

Lednicky et al. Virology Journal 2004 1:2   doi:10.1186/1743-422X-1-2