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Open Access Research

In vivo dose-response of insects to Hz-2V infection

John P Burand12* and Christopher P Rallis1

Author Affiliations

1 Department of Entomology, University of Massachusetts at Amherst, Amherst, Massachusetts, USA

2 Department of Microbiology, University of Massachusetts at Amherst, Amherst, Massachusetts, USA

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Virology Journal 2004, 1:15  doi:10.1186/1743-422X-1-15

Published: 21 December 2004



Hz-2V infection of female Helicoverpa zea moths is manifested as insects that are either sterile "agonadal" individuals with malformed reproductive tissues or fertile asymptomatic carriers which are capable of transmitting virus on to their progeny. Virus infected progeny arising from eggs laid by asymptomatic carrier females may themselves be either sterile agonadals or asymptomatic carriers.


By injecting virus into female moths, a correlation was established between virus doses administered to the females and the levels of resulting asymptomatic and sterile progeny.


The results of these experiments indicate that high virus doses produced a higher level of agonadal progeny and lower doses produced higher levels of asymptomatic carriers.